• Regeneration

    November 16-18, 2017, Milan Italy

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  • 14th ISNI Congress & 2nd GSNI Pre-Course

    August 27-31, 2018 - Brisbane, Australia

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Pathophysiology Research Center
Toulouse Purpan (CPTP-INSERM U1043-CNRS U5282

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1990: Medical Doctor degree and Medical Thesis, Paris
1991: Certification, Neurology Specialty Board
1995: PhD, in Immunology, Paris
1999: Accreditation to supervise Research programs
2001: Professor of Clinical Immunology, Toulouse

1983-1989: Residency program in Neurology, Paris
1994-2001: Head of the CSF analysis Laboratory, Salpêtrière Hospital, Paris
Since 2001: Professor of Clinical Immunology, Toulouse

1986: Master in Immunology, Paris (Pr J-F. Bach)
1989-1991: PhD student, Pasteur Institute (Dr M.A. Bach)
1991-1994: Post-doctoral position with Pr H. McDevitt, Stanford University, USA
1996-2002: Head of the Neuro-Immunology Research Team, INSERM CJF97-11 then INSERM U546, Paris
Since 2003: Head of the Autoimmunity and Immunoregulation Research Team, INSERM U563, Toulouse
Since 2007: Chairman of the Department of Immunology and Infectious Diseases, INSERM U563
Since 2009: Deputy Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U563)
Since 2011: Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U1043-CNRS U5282)

Medical and Scientific consultancy for:

INSERM; AFSSAPS (French FDA); French Research Ministry; AERES; ANR MIME and MIE (member of the evaluating committee)
French Multiple Sclerosis Society ; French Myopathy Foundation (AFM)
The Swiss Research foundation; Foundation for the support of MS research (Holland); DFG (Germany); EU FP7 programs; Medical Research Council (UK); Welcome Trust (UK); WHO (Switzerland); Institute of Medicine (USA); Broad Medical Research Program (USA)
Companies: Peptimmune and Biogen-Idec (USA); Teva pharma (Israël), Pasteur-Mérieux, Neurotech, AB science, Neovacs, Orphan Europe (France)

Reviewing of scientific articles:
Science; Journal of Clinical Investigation; Journal of Experimental Medicine; PNAS USA; Lancet; EMBO Journal; Trends in Immunology; Brain; Annals of Neurology; Acta Neuropathologica; Current Opinion in Immunology; Journal of Immunology; Neurology; PLoS genetics; American Journal of Pathology; European Journal of Immunology; Journal of Neuroimmunology; Neurobiology of Disease; GLIA;...

Editorial Board member:
Open Journal of Autoimmunity since 2008, Frontiers in Immune Tolerance since 2010, OncoImmunology since 2011, BRAIN Editorial Advisory Board since 2015.

Head of the EFNS Panel on Neuroimmunology (2003-06);
French Immunology Society Board member and President (2010-2012);
Scientific board member of the French MS society (ARSEP) since 2005;
Co-founder and member of the European School of Neuroimmunology (since 2000);
Member of the Teaching course committee for ECTRIMS and ACTRIMS/ECTRIMS congresses since 2009;
Since 2014, Member of the Executive Committee for ECTRIMS, the largest organization worldwide on research and treatment for multiple sclerosis.
Since 2016: Deputy Director of the Toulouse Excellence Center for Neurodegenerative Diseases (NeuroToul).

Selected Peer-reviewed Publications
1: R. Bernard-Valnet, L. Yshii, C. Quériault, X-H. Nguyen, S. Arthaud, M. Rodrigues, A. Canivet, A-L. Morel, A. Matthys, J. Bauer, B. Pignolet, Y. Dauvilliers, C. Peyron, and R.S. Liblau. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. PNAS (USA). Sep 12. pii: 201603325. [Epub ahead of print]
2: L. Yshii, C. Gebauer, B. Pignolet, E. Mauré, C. Quériault, M. Pierau, H. Saito, N. Suzuki, M. Brunner-Weinzierl, J. Bauer, RS. Liblau. CTLA-4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN. Sep 6. pii: aww225. [Epub ahead of print]
3: Martin-Blondel G, Brassat D, Bauer J, Lassmann H, Liblau RS. CCR5 blockade for neuroinflammatory diseases. Nat Rev Neurol. 2016 Feb;12(2):95-105.
4: A. Ramadan, L. Lucca, N. Carrié, S. Desbois-Beaumel, P-P. Axisa, J Bauer, RS. Liblau* and LT. Mars* In situ expansion of polyspecific T cells that recognize distinct self-antigens sustains the progression of organ-specific autoimmunity. BRAIN. 2016. 139(5):1433-46. *Shared last authorship.
5: Waisman A*, Liblau RS*, Becher B*. Innate and adaptive immune responses in the CNS. Lancet Neurol. 2015 Sep;14(9):945-55.
6: Liblau RS, Vassalli A, Seifinejad A, Tafti M. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Lancet Neurol. 2015 Mar;14(3):318-28.
7: Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrié N, Guéry JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS. Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice. J Immunol. 2014 Oct 1;193(7):3267-77
8: Martin-Blondel G, Bauer J, Cuvinciuc V, Uro-Coste E, Debard A, Massip P, Delisle MB, Lassmann H, Marchou B, Mars LT, Liblau RS. In situ evidence of JC virus control by CD8+ T cells in PML-IRIS during HIV infection. Neurology. 2013 Sep 10;81(11):964-7<0.
9: Liblau RS, Gonzalez-Dunia D, Wiendl H, Zipp F. Neurons as targets for T cells in the nervous system. Trends Neurosci. 2013 Jun;36(6):315-24.
10: Scheikl T, Pignolet B, Dalard C, Desbois S, Raison D, Yamazaki M, Saoudi A, Bauer J, Lassmann H, Hardin-Pouzet H, Liblau RS. Cutting edge: neuronal recognition by CD8 T cells elicits central diabetes insipidus. J Immunol. 2012 May 15;188(10):4731-5.
11: Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau RS, Wekerle H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med. 2009 15(6):626-32.
12: Mars LT, Araujo L, Kerschen P, Diem S, Bourgeois E, Van LP, Carrié N, Dy M, Liblau RS*, Herbelin A*. Invariant NKT cells inhibit development of the Th17 lineage. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6238-43. doi: 10.1073/pnas.0809317106.
13: Saxena A, Bauer J, Scheikl T, Zappulla J, Audebert M, Desbois S, Waisman A, Lassmann H, Liblau RS, Mars LT. Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J Immunol. 2008 Aug 1;181(3):1617-21.
14: Mars LT, Bauer J, Gross DA, Bucciarelli F, Firat H, Hudrisier D, Lemonnier F, Kosmatopoulos K, Liblau RS. CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A*0201-transgenic mice. J Immunol. 2007 Oct 15;179(8):5090-8.
15: Galea I, Bernardes-Silva M, Forse PA, van Rooijen N, Liblau RS, Perry VH. An antigen-specific pathway for CD8 T cells across the blood-brain barrier. J. Exp. Med. 2007 Sep 3;204(9):2023-30.
16: Piaggio E, Mars LT, Cassan C, Cabarrocas J, Hofstätter M, Desbois S, Bergereau E, Rötzschke O, Falk K, Liblau RS. Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9393-8.
17: Cassan C, Piaggio E, Zappulla JP, Mars LT, Couturier N, Bucciarelli F, Desbois S, Bauer J, Gonzalez-Dunia D, Liblau RS. Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. J Immunol. 2006 Aug 1;177(3):1552-60. PubMed PMID: 16849462.
18: Cabarrocas J, Cassan C, Magnusson F, Piaggio E, Mars L, Derbinski J, Kyewski B, Gross DA, Salomon BL, Khazaie K, Saoudi A, Liblau RS. Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8453-8. Epub 2006 May 18.
19: Zappulla JP, Dubreuil P, Desbois S, Létard S, Hamouda NB, Daëron M, Delsol G, Arock M, Liblau RS. Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. J Exp Med. 2005 19;202(12):1635-41.
20: Delarasse C, Daubas P, Mars LT, Vizler C, Litzenburger T, Iglesias A, Bauer J, Della Gaspera B, Schubart A, Decker L, Dimitri D, Roussel G, Dierich A, Amor S, Dautigny A*, Liblau R*, Pham-Dinh D*. Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest. 2003 Aug;112(4):544-53.

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