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  • 14th ISNI Congress

    14th International Congress of Neuroimmunology
    2nd Global Schools of Neuroimmunology Pre-Course

    August 27-31, 2018 - Brisbane, Australia

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  • ASNI Charlottesville 2017

    2nd Americas School of Neuroimmunology

    October 3-6, 2017 - Charlottesville (VA), USA

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  • ISNI SESSION - AAI 2017

    ISNI Session at the Immunology 2017 meeting

    Date: Monday, May 15, 2017
    Time: 10:15 AM - 12:15 PM

     
  • Registration and Abstract Submission

    Registration and Abstract Submission to the XXVI AINI Congress and 16th ESNI Course is open. Check it out here

     
  • Regeneration

    November 16-18, 2017, Milan Italy

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Liblau, Roland

Liblau

 

 

Director
Pathophysiology Research Center
Toulouse Purpan (CPTP-INSERM U1043-CNRS U5282

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EDUCATION:
1990: Medical Doctor degree and Medical Thesis, Paris
1991: Certification, Neurology Specialty Board
1995: PhD, in Immunology, Paris
1999: Accreditation to supervise Research programs
2001: Professor of Clinical Immunology, Toulouse

MEDICAL ACTIVITY
1983-1989: Residency program in Neurology, Paris
1994-2001: Head of the CSF analysis Laboratory, Salpêtrière Hospital, Paris
Since 2001: Professor of Clinical Immunology, Toulouse

RESERACH ACTIVITY
1986: Master in Immunology, Paris (Pr J-F. Bach)
1989-1991: PhD student, Pasteur Institute (Dr M.A. Bach)
1991-1994: Post-doctoral position with Pr H. McDevitt, Stanford University, USA
1996-2002: Head of the Neuro-Immunology Research Team, INSERM CJF97-11 then INSERM U546, Paris
Since 2003: Head of the Autoimmunity and Immunoregulation Research Team, INSERM U563, Toulouse
Since 2007: Chairman of the Department of Immunology and Infectious Diseases, INSERM U563
Since 2009: Deputy Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U563)
Since 2011: Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U1043-CNRS U5282)

CONSULTING AND REVIEWING
Medical and Scientific consultancy for:

INSERM; AFSSAPS (French FDA); French Research Ministry; AERES; ANR MIME and MIE (member of the evaluating committee)
French Multiple Sclerosis Society ; French Myopathy Foundation (AFM)
The Swiss Research foundation; Foundation for the support of MS research (Holland); DFG (Germany); EU FP7 programs; Medical Research Council (UK); Welcome Trust (UK); WHO (Switzerland); Institute of Medicine (USA); Broad Medical Research Program (USA)
Companies: Peptimmune and Biogen-Idec (USA); Teva pharma (Israël), Pasteur-Mérieux, Neurotech, AB science, Neovacs, Orphan Europe (France)

Reviewing of scientific articles:
Science; Journal of Clinical Investigation; Journal of Experimental Medicine; PNAS USA; Lancet; EMBO Journal; Trends in Immunology; Brain; Annals of Neurology; Acta Neuropathologica; Current Opinion in Immunology; Journal of Immunology; Neurology; PLoS genetics; American Journal of Pathology; European Journal of Immunology; Journal of Neuroimmunology; Neurobiology of Disease; GLIA;...

Editorial Board member:
Open Journal of Autoimmunity since 2008, Frontiers in Immune Tolerance since 2010, OncoImmunology since 2011, BRAIN Editorial Advisory Board since 2015.

SCIENTIFIC SOCIETY RESPONSABILITIES
Head of the EFNS Panel on Neuroimmunology (2003-06);
French Immunology Society Board member and President (2010-2012);
Scientific board member of the French MS society (ARSEP) since 2005;
Co-founder and member of the European School of Neuroimmunology (since 2000);
Member of the Teaching course committee for ECTRIMS and ACTRIMS/ECTRIMS congresses since 2009;
Since 2014, Member of the Executive Committee for ECTRIMS, the largest organization worldwide on research and treatment for multiple sclerosis.
Since 2016: Deputy Director of the Toulouse Excellence Center for Neurodegenerative Diseases (NeuroToul).

Selected Peer-reviewed Publications
1: R. Bernard-Valnet, L. Yshii, C. Quériault, X-H. Nguyen, S. Arthaud, M. Rodrigues, A. Canivet, A-L. Morel, A. Matthys, J. Bauer, B. Pignolet, Y. Dauvilliers, C. Peyron, and R.S. Liblau. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. PNAS (USA). Sep 12. pii: 201603325. [Epub ahead of print]
2: L. Yshii, C. Gebauer, B. Pignolet, E. Mauré, C. Quériault, M. Pierau, H. Saito, N. Suzuki, M. Brunner-Weinzierl, J. Bauer, RS. Liblau. CTLA-4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN. Sep 6. pii: aww225. [Epub ahead of print]
3: Martin-Blondel G, Brassat D, Bauer J, Lassmann H, Liblau RS. CCR5 blockade for neuroinflammatory diseases. Nat Rev Neurol. 2016 Feb;12(2):95-105.
4: A. Ramadan, L. Lucca, N. Carrié, S. Desbois-Beaumel, P-P. Axisa, J Bauer, RS. Liblau* and LT. Mars* In situ expansion of polyspecific T cells that recognize distinct self-antigens sustains the progression of organ-specific autoimmunity. BRAIN. 2016. 139(5):1433-46. *Shared last authorship.
5: Waisman A*, Liblau RS*, Becher B*. Innate and adaptive immune responses in the CNS. Lancet Neurol. 2015 Sep;14(9):945-55.
6: Liblau RS, Vassalli A, Seifinejad A, Tafti M. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Lancet Neurol. 2015 Mar;14(3):318-28.
7: Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrié N, Guéry JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS. Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice. J Immunol. 2014 Oct 1;193(7):3267-77
8: Martin-Blondel G, Bauer J, Cuvinciuc V, Uro-Coste E, Debard A, Massip P, Delisle MB, Lassmann H, Marchou B, Mars LT, Liblau RS. In situ evidence of JC virus control by CD8+ T cells in PML-IRIS during HIV infection. Neurology. 2013 Sep 10;81(11):964-7<0.
9: Liblau RS, Gonzalez-Dunia D, Wiendl H, Zipp F. Neurons as targets for T cells in the nervous system. Trends Neurosci. 2013 Jun;36(6):315-24.
10: Scheikl T, Pignolet B, Dalard C, Desbois S, Raison D, Yamazaki M, Saoudi A, Bauer J, Lassmann H, Hardin-Pouzet H, Liblau RS. Cutting edge: neuronal recognition by CD8 T cells elicits central diabetes insipidus. J Immunol. 2012 May 15;188(10):4731-5.
11: Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau RS, Wekerle H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med. 2009 15(6):626-32.
12: Mars LT, Araujo L, Kerschen P, Diem S, Bourgeois E, Van LP, Carrié N, Dy M, Liblau RS*, Herbelin A*. Invariant NKT cells inhibit development of the Th17 lineage. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6238-43. doi: 10.1073/pnas.0809317106.
13: Saxena A, Bauer J, Scheikl T, Zappulla J, Audebert M, Desbois S, Waisman A, Lassmann H, Liblau RS, Mars LT. Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J Immunol. 2008 Aug 1;181(3):1617-21.
14: Mars LT, Bauer J, Gross DA, Bucciarelli F, Firat H, Hudrisier D, Lemonnier F, Kosmatopoulos K, Liblau RS. CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A*0201-transgenic mice. J Immunol. 2007 Oct 15;179(8):5090-8.
15: Galea I, Bernardes-Silva M, Forse PA, van Rooijen N, Liblau RS, Perry VH. An antigen-specific pathway for CD8 T cells across the blood-brain barrier. J. Exp. Med. 2007 Sep 3;204(9):2023-30.
16: Piaggio E, Mars LT, Cassan C, Cabarrocas J, Hofstätter M, Desbois S, Bergereau E, Rötzschke O, Falk K, Liblau RS. Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9393-8.
17: Cassan C, Piaggio E, Zappulla JP, Mars LT, Couturier N, Bucciarelli F, Desbois S, Bauer J, Gonzalez-Dunia D, Liblau RS. Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. J Immunol. 2006 Aug 1;177(3):1552-60. PubMed PMID: 16849462.
18: Cabarrocas J, Cassan C, Magnusson F, Piaggio E, Mars L, Derbinski J, Kyewski B, Gross DA, Salomon BL, Khazaie K, Saoudi A, Liblau RS. Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8453-8. Epub 2006 May 18.
19: Zappulla JP, Dubreuil P, Desbois S, Létard S, Hamouda NB, Daëron M, Delsol G, Arock M, Liblau RS. Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. J Exp Med. 2005 19;202(12):1635-41.
20: Delarasse C, Daubas P, Mars LT, Vizler C, Litzenburger T, Iglesias A, Bauer J, Della Gaspera B, Schubart A, Decker L, Dimitri D, Roussel G, Dierich A, Amor S, Dautigny A*, Liblau R*, Pham-Dinh D*. Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest. 2003 Aug;112(4):544-53.

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