3rd Esni Course | 11-14 September 2002
Program DAY ONE
Chairs: G. Martino – T. Olsson
Regulatory immune-responses in the nervous system
9.00-09.40
An overview on regulatory T cells (D. Wraith)
09.45-10.25
The dual role of NKT cells in autoimmunity (L. Van Kaer)
10.30-11.00
Coffee Break
11.00-11.40
Evasion of clearance by CD8+ cells in autoimmunity (M. Brahic)
11.45-12.25
The genetics of complex traits (D.A.S. Compston)
12.30-15.00
Lunch with the expert
15.00-15.40
The role of T cells in the nervous system
A general overview (H. Wekerle)
15.45-16.25
Antigen specific CD8+ T cells in EAE/MS (R. Liblau)
16.30-17.00
Tea Break
16:30-17:00
Coffee break
17.00-17.40
Regulation of the immune response by resident cells
of the central nervous system (Robert Darnell)
17:00-17:40
The role of inflammation in neurodegenerative disorders (J. Antel)
17.45-18.25
The role of CD8+ cells in myositis (R. Gold)
17.45-18.25
Welcome Reception (Offered by SCHERING)
DAY TWO
Chairs: A. Vincent Ð – N.E. Gilhus
Humoral factors in neurological diseases
09:00 – 09:40
FMechanisms of tolerance to self and of its breakdown in autoimmune diseases (J. F. Bach)
09:50 – 10:30
Th1-Th2 immune response and its regulation (J. Andersson)
10:40 – 11:00
Coffee break
11:00 – 11:40
Regulatory T cells (E. E. Sercarz)
11:50 – 12:30
Folding and degradation of proteins synthesized in the endoplasmic reticulum(R. Sitia)
12:40 – 15:00
Lunch
15:00 – 15:40
Regulation of the immune response in the brain (H. Wekerle)
14.45 – 15.30
Microglia-axon interactions (H. Neumann)
15:50 – 16:30
The Th1 vs. Th2 paradigm in EAE/MS (J. J. Lafaille)
16:30 – 17:00
Coffee break
17:00 – 17:40
CParaneoplastic disorders affecting the peripheral and central nervous system (C. Vedeler)
17:50 – 18:30
Relevant and irrelevant antibodies in peripheral nerve disorders (H. Willison)
DAY THREE
Chairs: G. Comi – X. Montalban
Immunotherapy
09:00 – 09:40
Strategies for selective immunosuppression(L. Adorini)
09:50 – 10:30
Immunoregulatory effects of steroids(E. Arzt)
10:40 – 11:00
Coffee break
11:00 – 11:40
T cell targeting and antigen-driven immunotherapies (A. Miller)
11:50 – 12:30
Immunomodulatory gene therapy in demyelinating disorders
(G. Martino)
12:40 – 15:00
Lunch
15:00 – 15:40
Thymectomy in neurological autoimmune diseases; does it work and if so why?(N. Gilhus)
15:50 – 16:30
IvIg in neuromuscular and PNS disorders(F. G. A. van der Mechè)
16:30 – 17:00
Coffee break
17:00 – 17:40
MMPs as target molecules in immuno-mediated diseases of the CNS and PNS(H. P. Hartung)
17:50 – 18:30
The logic of immunointervention: the combination therapies in CNS and PNS disorders (R. Hohlfeld)
DAY FOUR
Chairs: R. Weissert – G. Ebers
Genetics
09:00 – 09:40
Principles for genetic analysis of complex diseases in animals (H. Luthman)
09:50 – 10:30
The non-MHC genetics of experimental autoimmune diseases (R. Holmdahl)
10:40 – 11:00
Coffee break
11:00 – 11:40
Polygenic influences-epistatic interactions, speed congenics (E. Wakeland)
11:50 – 12:30
The role of MHC influences in experimental autoimmune disease (E. Wallström)
12:40 – 15:00
Lunch
15:00 – 15:40
The non MHC genetics of rat neuroinflammation: MOG-EAE-neurodegeneration (T. Olsson)
15:50 – 16:30
The genetics of MS (A. Compston)
16:30 – 17:00
Coffee break
17:00 – 17:40
The MHC/HLA (J. Hillert)
17:50 – 18:30
Experimental approaches to examine the DR2 influence on MS (L. Fugger)
18:30 – 18:45
Concluding remarks Gala Dinner
Organizing Committee
• Luciano Adorini (Italy)
• Nils E. Gilhus (Norway)
• Gianvito Martino (Italy)
• Ariel Miller (Israel)
• Tomas Olsson (local organizer, Sweden)
Chairs and Speakers
• Adorini, Luciano (Italy)
• Andersson, Jan (Sweden)
• Arzt, Eduardo (Argentina)
• Bach, Jean-Francois (France)
• Comi, Giancarlo (Italy)
• Compston, Alastair (United Kingtom)
• Ebers, George (United Kingtom)
• Fugger, Lars (Denmark)
• Gilhus, Nils E. (Norway)
• Grandien, Alf (Sweden)
• Hartung, Hans Peter(Austria)
• Hillert, Jan (Sweden)
• Hohlfeld, Reinhard (Germany)
• Holmdahl, Rikard (Sweden)
• Karre, Klas (Sweden)
• Lafaille, Juan J. (USA)
• Lassmann, Hans (Austria)
• Linington, Christopher (Germany)
• Luthman, Holger (Sweden)
• Martino, Gianvito (Italy)
• Miller, Ariel (Israel)
• Montalban, Xavier(Spain)
• Olsson, Tomas (Sweden)
• Piehl, Fredrik (Sweden)
• Ransohoff , Richard M.(USA)
• Scolding, Neil (United Kingdom)
• Sercarz, Eli E. (USA)
• Sitia, Roberto (Italy)
• Sozzani, Silvano (Italy)
• van der Mechè, Franz G.A. (The Netherlands)
• Vedeler, Christian (Norway)
• Vincent, Angela (United Kingdom)
• von Herrath, Matthias G. (USA)
• Wakeland, Edward (USA)
• Wallström, Erik(Sweden)
• Weissert, Robert (Germany)
• Wekerle, Hartmut (Germany)
• Willison, Hugh J. (United Kingdom)
