4th ESNI Course | 28 September -1 October 2003
DAY ONE
Chairs: H. Willison, G. Martino
Innate Immunity and Brain Functions
09.00 – 09.45
Innate Immunity in the CNS: friend or foe?
(P. Gasque)
09.45 – 10.30
Cytokines: multifunctional mediators in autoimmunity and stroke (G. Stoll)
10.30-11.00
Coffee Break
11.00-11.45
Resident macrophage responses in the peripheral nervous system (R. Kiefer)
11.45-12.30
Nitric oxide: its effects on the nervous system in inflammatory demyelinating disease (K. Smith)
12.30-14.30
Lunch with the experts
14.30-15.15
Complement activation products and regulators in neuroinflammation (P. Morgan)
15.15-16.00
The properties and functions of siglecs in the immune system (P. Crocker)
16.00-16.30
Coffee Break
16.30-17.15
The functional role of CD1 in neuroinflammatory diseases (G. De Libero)
17.15-18.00
Toll receptor biology in the central nervous system (J.M. van Noort)
DAY TWO
Chairs: L. Probert, N-E. Gilhus
Neurodegeneration and Immunoregulation
09.00-09.45
Protective vs. detrimental autoimmunity (V. Barnaba)
09.45-10.30
Induction of tolerance in autoimmune demyelination (D. Baker)
10.30-11.00
Coffee break
11:00-11:45
Macrophages in neurodegeneration (C. Dijkstra)
11.45-12.30
The protective properties of nitric oxide(NO) donors in neuroinflammation (E. Ongini)
12.30-14.30
Lunch with the experts
14.30-15.15
Synaptic apoptosis in immune-mediated destruction and remodeling of neuronal connections (M. P. Mattson)
15.15-16.00
Immunoregulatory mechanisms in neuroprotection (E. Taoufik)
16.00-16.30
Coffee break
16.30-17.15
Immunotherapy of Alzheimer’s disease (R. Nitsch)
17.15-18.00
Therapeutic approaches to neurodegeneration: tissue protective cytokines (P. Ghezzi)
DAY THREE
Chairs: F. Graus, A. Saiz
Relevance of autoantibody research in neuroimmunology
09.00-09.45
Autoantibodies as diagnostic tools in neuroimmunology: An overview on CNS disorders (F. Graus)
09.45-10.30
Autoantibodies as diagnostic tools in neuroimmunology: An overview on PNS disorders (E. Nobile Orazio)
10.30-11.00
Coffee break
11.00-11.45
Screening of DNA libraries and proteomics as new tools for detection of relevant autoantibodies (J. Dalmau)
11.45-12.30
Humoral autoimmunity as a mediator of CNS repair (M. Rodriguez)
12.30-14.30
Lunch with the experts
14.30-15.15
Rasmussen’s encephalitis: an autoantibody mediated disorder? (R. Mantegazza)
15.15-16.00
Anti-gliadin antibodies and cerebellar ataxia. A new syndrome? (M. Hadjivassiliou)
16.00-16.30
Coffee break
16.30-17.15
Immunological aspects of GAD autoimmunity in neurological disorders (A. Saiz and D. Jaraquemada )
17.15-18.00
Relevance of autoantibodies in Multiple Sclerosis (J. Archelos)
20.00-24.00
Social Dinner
DAY FOUR
Chairs: X. Montalban, G. Comi
Immunotherapies in Neuroimmunology
09.00-09.45
Genomic variations and clinical response to immunotherapy (J. Oksenberg)
09.45-10.30
Modelling autoimmunity of the nervous system in animals: relevance for therapy (T. Olsson)
10.30-11.00
Coffee break
11.00-11.45
Gene therapy of autoimmune disorders (Y. Chernajovsky)
11.45-12.30
Neuroprotection in neurological disorders using cell therapy (E. Snyder)
12.30-14.30
Lunch with the experts
14.30-15.15
Current concepts of multiple sclerosis therapy (X. Montalban)
15.15-16.00
Pathogenetic heterogeneity of multiple sclerosis lesions: implications for treatment (W. Brück)
16.00-16.30
Coffee break
16.30-17.15
Basis of immunotherapy of PNS inflammatory diseases (B. Kieseier)
17.15-18.00
T cell receptor immunotherapy in immuno-mediated diseases of the CNS (P. Stinissen)
Organizing Committee
• Xavier Montalban (local organizer, Spain)
• Nils Erik Gilhus (Norway)
• Francesc Graus (Spain)
• Gianvito Martino (Italy)
• Lesley Probert (Greece)
• Hugh Willison (United Kingdom)
Chairs and Speakers
• Archelos, Juan (Graz, Austria)
• Baker, David (London, United Kingdom)
• Barnaba, Vincenzo (Rome, Italy)
• Brück, Wolfgang (Göttingen, Germany)
• Chernajovsky, Yuti (London, United Kingdom)
• Comi, Giancarlo (Milan, Italy)
• Crocker, Paul (Dundee, United Kingdom)
• Dalmau, Josep (Philadelphia, United States)
• De Libero, Gennaro (Basel, Switzerland)
• Dijkstra, Christine (Amsterdam, The Netherlands)
• Gasque, Philippe (Cardiff, United Kingdom)
• Ghezzi, Pietro (Milan, Italy)
• Gilhus, Nils Erik (Bergen, Norway)
• Graus, Francesc (Barcelona, Spain)
• Hartung, Hans-Peter (Düsseldorf, Germany)
• Jaraquemada, Dolores (Barcelona, Spain)
• Kiefer, Reinhard (Munster, Germany)
• Kieseier, Bernd (Duesseldorf, Germany)
• Mantegazza, Renato (Milan, Italy)
• Martino, Gianvito (Milan, Italy)
• Mattson, Mark P. (Baltimore, United States)
• Montalban, Xavier (Barcelona, Spain)
• Morgan, Bryan P. (Cardiff, United Kingdom)
• Nitsch, Roger (Zurich, Switzerland)
• Nobile Orazio, Eduardo (Milan, Italy)
• Oksenberg, Jorge (San Francisco, United States)
• Olsson, Tomas (Stockholm, Sweden)
• Ongini, Ennio (Milan, Italy)
• Probert, Lesley (Athens, Greece)
• Rodriguez, Moses (Rochester, United States)
• Saiz, Albert (Barcelona, Spain)v
• Smith, Kenneth J. (London, United Kingdom)
• Snyder, Evan (United States)
• Stinissen, Piet (Diepen, Belgium)
• Stoll, Guido (Würzburg, Germany)
• Taoufik, Era (Athens, Greece)
• Van Noort, Johannes M. (Leiden, The Netherlands)
• Willison, Hugh J. (Glasgow, United Kingdom)
