Barcelona 2003

20 February 2003
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4th ESNI Course | 28 September -1 October 2003

DAY ONE
Chairs: H. Willison, G. Martino

Innate Immunity and Brain Functions

09.00 – 09.45
Innate Immunity in the CNS: friend or foe?
(P. Gasque)

09.45 – 10.30
Cytokines: multifunctional mediators in autoimmunity and stroke (G. Stoll)

10.30-11.00
Coffee Break

11.00-11.45
Resident macrophage responses in the peripheral nervous system (R. Kiefer)

11.45-12.30
Nitric oxide: its effects on the nervous system in inflammatory demyelinating disease (K. Smith)

12.30-14.30
Lunch with the experts

14.30-15.15
Complement activation products and regulators in neuroinflammation (P. Morgan)

15.15-16.00
The properties and functions of siglecs in the immune system (P. Crocker)

16.00-16.30
Coffee Break

16.30-17.15
The functional role of CD1 in neuroinflammatory diseases (G. De Libero)

17.15-18.00
Toll receptor biology in the central nervous system (J.M. van Noort)

DAY TWO
Chairs: L. Probert, N-E. Gilhus

Neurodegeneration and Immunoregulation

09.00-09.45
Protective vs. detrimental autoimmunity (V. Barnaba)

09.45-10.30
Induction of tolerance in autoimmune demyelination (D. Baker)

10.30-11.00
Coffee break

11:00-11:45
Macrophages in neurodegeneration (C. Dijkstra)

11.45-12.30
The protective properties of nitric oxide(NO) donors in neuroinflammation (E. Ongini)

12.30-14.30
Lunch with the experts

14.30-15.15
Synaptic apoptosis in immune-mediated destruction and remodeling of neuronal connections (M. P. Mattson)

15.15-16.00
Immunoregulatory mechanisms in neuroprotection (E. Taoufik)

16.00-16.30
Coffee break

16.30-17.15
Immunotherapy of Alzheimer’s disease (R. Nitsch)

17.15-18.00
Therapeutic approaches to neurodegeneration: tissue protective cytokines (P. Ghezzi)

DAY THREE
Chairs: F. Graus, A. Saiz

Relevance of autoantibody research in neuroimmunology

09.00-09.45
Autoantibodies as diagnostic tools in neuroimmunology: An overview on CNS disorders (F. Graus)

09.45-10.30
Autoantibodies as diagnostic tools in neuroimmunology: An overview on PNS disorders (E. Nobile Orazio)

10.30-11.00
Coffee break

11.00-11.45
Screening of DNA libraries and proteomics as new tools for detection of relevant autoantibodies (J. Dalmau)

11.45-12.30
Humoral autoimmunity as a mediator of CNS repair (M. Rodriguez)

12.30-14.30
Lunch with the experts

14.30-15.15
Rasmussen’s encephalitis: an autoantibody mediated disorder? (R. Mantegazza)

15.15-16.00
Anti-gliadin antibodies and cerebellar ataxia. A new syndrome? (M. Hadjivassiliou)

16.00-16.30
Coffee break

16.30-17.15
Immunological aspects of GAD autoimmunity in neurological disorders (A. Saiz and D. Jaraquemada )

17.15-18.00
Relevance of autoantibodies in Multiple Sclerosis (J. Archelos)

20.00-24.00
Social Dinner

DAY FOUR
Chairs: X. Montalban, G. Comi

Immunotherapies in Neuroimmunology

09.00-09.45
Genomic variations and clinical response to immunotherapy (J. Oksenberg)

09.45-10.30
Modelling autoimmunity of the nervous system in animals: relevance for therapy (T. Olsson)

10.30-11.00
Coffee break

11.00-11.45
Gene therapy of autoimmune disorders (Y. Chernajovsky)

11.45-12.30
Neuroprotection in neurological disorders using cell therapy (E. Snyder)

12.30-14.30
Lunch with the experts

14.30-15.15
Current concepts of multiple sclerosis therapy (X. Montalban)

15.15-16.00
Pathogenetic heterogeneity of multiple sclerosis lesions: implications for treatment (W. Brück)

16.00-16.30
Coffee break

16.30-17.15
Basis of immunotherapy of PNS inflammatory diseases (B. Kieseier)

17.15-18.00
T cell receptor immunotherapy in immuno-mediated diseases of the CNS (P. Stinissen)

Organizing Committee

• Xavier Montalban (local organizer, Spain)
• Nils Erik Gilhus (Norway)
• Francesc Graus (Spain)
• Gianvito Martino (Italy)
• Lesley Probert (Greece)
• Hugh Willison (United Kingdom)

Chairs and Speakers

• Archelos, Juan (Graz, Austria)
• Baker, David (London, United Kingdom)
• Barnaba, Vincenzo (Rome, Italy)
• Brück, Wolfgang (Göttingen, Germany)
• Chernajovsky, Yuti (London, United Kingdom)
• Comi, Giancarlo (Milan, Italy)
• Crocker, Paul (Dundee, United Kingdom)
• Dalmau, Josep (Philadelphia, United States)
• De Libero, Gennaro (Basel, Switzerland)
• Dijkstra, Christine (Amsterdam, The Netherlands)
• Gasque, Philippe (Cardiff, United Kingdom)
• Ghezzi, Pietro (Milan, Italy)
• Gilhus, Nils Erik (Bergen, Norway)
• Graus, Francesc (Barcelona, Spain)
• Hartung, Hans-Peter (Düsseldorf, Germany)
• Jaraquemada, Dolores (Barcelona, Spain)
• Kiefer, Reinhard (Munster, Germany)
• Kieseier, Bernd (Duesseldorf, Germany)
• Mantegazza, Renato (Milan, Italy)
• Martino, Gianvito (Milan, Italy)
• Mattson, Mark P. (Baltimore, United States)
• Montalban, Xavier (Barcelona, Spain)
• Morgan, Bryan P. (Cardiff, United Kingdom)
• Nitsch, Roger (Zurich, Switzerland)
• Nobile Orazio, Eduardo (Milan, Italy)
• Oksenberg, Jorge (San Francisco, United States)
• Olsson, Tomas (Stockholm, Sweden)
• Ongini, Ennio (Milan, Italy)
• Probert, Lesley (Athens, Greece)
• Rodriguez, Moses (Rochester, United States)
• Saiz, Albert (Barcelona, Spain)v
• Smith, Kenneth J. (London, United Kingdom)
• Snyder, Evan (United States)
• Stinissen, Piet (Diepen, Belgium)
• Stoll, Guido (Würzburg, Germany)
• Taoufik, Era (Athens, Greece)
• Van Noort, Johannes M. (Leiden, The Netherlands)
• Willison, Hugh J. (Glasgow, United Kingdom)

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