Tuesday April 27
DATE: Tuesday April 27, 2021ARTICLE: Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.Science Direct Link: https://www.sciencedirect.com/science/article/pii/S0092867420302129MODERATOR: Maja Jagodic (Karolinska Institutet - Stockholm, Sweden)AUTHORS: Aiden Haghikia and Alexander Duscha(Ruhr University Bochum - Bochum, Germany)PRESENTER: Nicolas Ruffin(Karolinska Institutet - Stockholm, Sweden)
Tuesday March 30
DATE: Tuesday March 30, 2022ARTICLE: Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesisNature Neuroscience Link: https://www.nature.com/articles/s41593-020-00757-6 MODERATORS: Maja Jagodic (Karolinska Institutet - Stockholm, Sweden)AUTHORS: Gesine Saher and Stefan Berghoff(Max Planck Institute of Experimental Medicine - Göttingen, Germany)PRESENTER: Andre Ortlieb Guerreiro-Cacais(Karolinska Institutet - Stockholm, Sweden)
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
ESNI Journal Club March 30, 2021 at 3:00pm CET ESNI will host Dr. Gesine Saher and Dr. Stefano Berghoff (Max Plank Institute of Experimental Medicine, Germany) to answer question about there article Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. “The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subsequently, oligodendrocytes increase cholesterol levels as a prerequisite for synthesizing new myelin membranes. We hypothesized that lesion resolution is regulated by the fate of cholesterol from damaged myelin [...]
