Pathophysiology Research Center
Toulouse Purpan (CPTP-INSERM UMR 1043-CNRS UMR 5282)
1990: Medical Doctor degree and Medical Thesis, Paris
1991: Certification, Neurology Specialty Board
1995: PhD, in Immunology, Paris
1999: Accreditation to supervise Research programs
2001: Professor of Clinical Immunology, Toulouse
1983-1989: Residency program in Neurology, Paris
1994-2001: Head of the CSF analysis Laboratory, Salpêtrière Hospital, Paris
Since 2001: Professor of Clinical Immunology, Toulouse
1986: Master in Immunology, Paris (Pr J-F. Bach)
1989-1991: PhD student, Pasteur Institute (Dr M.A. Bach)
1991-1994: Post-doctoral position with Pr H. McDevitt, Stanford University, USA
1996-2002: Head of the Neuro-Immunology Research Team, INSERM CJF97-11 then INSERM U546, Paris
Since 2003: Head of the Autoimmunity and Immunoregulation Research Team, INSERM U563, Toulouse
Since 2007: Chairman of the Department of Immunology and Infectious Diseases, INSERM U563
Since 2009: Deputy Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U563)
Since 2011: Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U1043-CNRS U5282)
CONSULTING AND REVIEWING
Medical and Scientific consultancy for:
INSERM; AFSSAPS (French FDA); French Research Ministry; AERES; ANR MIME and MIE (member of the evaluating committee)
French Multiple Sclerosis Society ; French Myopathy Foundation (AFM)
The Swiss Research foundation; Foundation for the support of MS research (Holland); DFG (Germany); EU FP7 programs; Medical Research Council (UK); Welcome Trust (UK); WHO (Switzerland); Institute of Medicine (USA); Broad Medical Research Program (USA)
Companies: Peptimmune and Biogen-Idec (USA); Teva pharma (Israël), Pasteur-Mérieux, Neurotech, AB science, Neovacs, Orphan Europe (France)
Reviewing of scientific articles:
Nature; Science; Nature Medicine; Nature Reviews Neurology; Immunity; Science Translational Medicine; Journal of Clinical Investigation; Journal of Experimental Medicine; PNAS USA; Lancet; Nature Communications; EMBO Journal; Trends in Immunology; Brain; Annals of Neurology; Acta Neuropathologica; Current Opinion in Immunology; Journal of Immunology; Neurology; PLoS genetics; American Journal of Pathology; European Journal of Immunology; Journal of Neuroimmunology; Neurobiology of Disease; GLIA;…
Editorial Board member:
Open Journal of Autoimmunity since 2008, Frontiers in Immune Tolerance since 2010, OncoImmunology since 2011, BRAIN Editorial Advisory Board since 2015.
SCIENTIFIC SOCIETY RESPONSABILITIES
- French Immunology Society (SFI) Board member (2009-2012)
- President of the SFI from Jan 2010 to Dec 2012.
- Scientific board member of the French MS society (ARSEP);
- Head of the EFNS Panel on Neuroimmunology (2003-06);
- Co-founder and member of the European School of Neuroimmunology (since 2000).
- Member of the Teaching course committee for ECTRIMS and ACTRIMS/ECTRIMS congresses since 2009.
- Since 2014, Member of the Executive Committee for ECTRIMS, the largest organization worldwide on research and treatment for multiple sclerosis.
- Since 2014, Member of the International Advisory Board of the International Society of NeuroImmunology(ISNI)
- Since 2017, member of the Henry Kunkel Society, New York, USA.Since 2016: Deputy Director of the Toulouse Excellence Center for Neurodegenerative Diseases (NeuroToul).
Selected Peer-reviewed Publications
1: Liblau RS. Put to sleep by immune cells. Nature2018; 562: 46-48 News & Views.
2:Nguyen XH, Dauvilliers Y, Quériault C, Perals C, Romieu-Mourez R, Paulet PE, Bernard-Valnet R, Fazilleau N, Liblau R. Circulating follicular helper T cells exhibit reduced ICOS expression and impaired function in narcolepsy type 1 patients.J. Autoimmun. 2018 Aug 6. pii: S0896-8411(18)30230-0.
3: Yshii L, Hohlfeld R, Liblau R. Inflammatory diseases of the CNS caused by immune checkpoint inhibitors: status and perspectives.Nat Rev Neurol.2017Dec;13(12):755-763.
4:C. Gebauer, B. Pignolet, L. Yshii,E. Mauré, J. Bauer, R. Liblau. CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model. Oncoimmunology. 2016 Dec 9;6(2):e1260212. doi: 10.1080/2162402X.2016.1260212. eCollection 2017.
5:F.J. Hartmann, R. Bernard-Valnet, C. Quériault, D. Mrdjen, L.M. Weber, E. Galli, C. Krieg, M.D. Robinson, X-H. Nguyen, Y. Dauvilliers, R.S. Liblau*& B. Becher*. High-Dimensional Single-Cell Analysis Reveals The Immune Signature of Narcolepsy J. Exp. Med.Nov 14;213(12):2621-2633. *Shared last authorship.
6:R. Bernard-Valnet, L. Yshii, C. Quériault, X-H. Nguyen, S. Arthaud, M. Rodrigues, A. Canivet, A-L. Morel, A. Matthys, J. Bauer, B. Pignolet, Y. Dauvilliers, C. Peyron, and R.S. Liblau. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. PNAS (USA). Sep 12. pii: 201603325. [Epub ahead of print]
7: L. Yshii, C. Gebauer, B. Pignolet, E. Mauré, C. Quériault, M. Pierau, H. Saito, N. Suzuki, M. Brunner-Weinzierl, J. Bauer, RS. Liblau. CTLA-4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN. Sep 6. pii: aww225. [Epub ahead of print]
8: Martin-Blondel G, Brassat D, Bauer J, Lassmann H, Liblau RS. CCR5 blockade for neuroinflammatory diseases. Nat Rev Neurol. 2016 Feb;12(2):95-105.
9: A. Ramadan, L. Lucca, N. Carrié, S. Desbois-Beaumel, P-P. Axisa, J Bauer, RS. Liblau* and LT. Mars* In situ expansion of polyspecific T cells that recognize distinct self-antigens sustains the progression of organ-specific autoimmunity. BRAIN. 2016. 139(5):1433-46. *Shared last authorship.
10: Waisman A*, Liblau RS*, Becher B*. Innate and adaptive immune responses in the CNS. Lancet Neurol. 2015 Sep;14(9):945-55.
11: Liblau RS, Vassalli A, Seifinejad A, Tafti M. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Lancet Neurol. 2015 Mar;14(3):318-28.
12: Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrié N, Guéry JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS. Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice. J Immunol. 2014 Oct 1;193(7):3267-77
13: Martin-Blondel G, Bauer J, Cuvinciuc V, Uro-Coste E, Debard A, Massip P, Delisle MB, Lassmann H, Marchou B, Mars LT, Liblau RS. In situ evidence of JC virus control by CD8+ T cells in PML-IRIS during HIV infection. Neurology.2013 Sep 10;81(11):964-7<0.
14: Liblau RS, Gonzalez-Dunia D, Wiendl H, Zipp F. Neurons as targets for T cells in the nervous system. Trends Neurosci. 2013 Jun;36(6):315-24.
15: Scheikl T, Pignolet B, Dalard C, Desbois S, Raison D, Yamazaki M, Saoudi A, Bauer J, Lassmann H, Hardin-Pouzet H, Liblau RS. Cutting edge: neuronal recognition by CD8 T cells elicits central diabetes insipidus. J Immunol. 2012 May 15;188(10):4731-5.
16: Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau RS, Wekerle H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med. 2009 15(6):626-32.
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